As we know, the use of each technology has several disadvantages. For example, the formation of salt is a complex process, in which the increase of solubility is not always predictable. This method is not suitable for neutral compound 37. As another examp
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Reducing the particle size and properties of the active ingredients or excipients is important in every stage of solid preparation manufacturing (micronization and transformation). The particle size affects the mixing, granulation, tableting, and coating
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The process of drug-dissolved molecules separating from the solid surface and entering the surrounding solution phase is called the dissolution process. Dissolution is a kinetic process that is usually controlled by diffusion.
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The preparations can be taken orally, parenterally, in the eyes, and in the lungs. Smaller particle sizes are required for rapid dissolution in the body or arterial uptake. However, slow-release or mononuclear macrophage targeting is better for larger par
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Through the method of preparing granular medicine, cortexin, a poorly soluble antioxidant, has the dissolution rate.
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Someone tried to improve the bioavailability and dissolution rate by preparing crystalline particles of 638.7nm-814.8nm. Under the premise of sodium lauryl sulfate as a stabilizer, anti-solvent precipitation technology is used.
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They found that the authors used spray drying to dry the crystals. It is inferred that the improvement of PRX dissolution is mainly attributed to another study. Lai and his colleagues used high-pressure homogenization and poloxamer 188 as a stabilizer to
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This formulation should also work. Itraconazole is a low water solubility. They use Poloxamer 407 as a stabilizer and glycerin as a wetting agent. And has low bioavailability. Modified into standard dosage forms such as capsules and tablets for oral use.
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By improving the solubility, it has been studied that it has a rapid dissolution rate so that it can be released within 30 minutes. In vitro studies have shown that this limits their bioavailability.
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The reduction of the particle size of felodipine is a good way to improve the application of particles with low water solubility and technical problems. There are various benefits and a good method of dissolution, but there is the possibility of disorder
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